MRI Monitoring of Changes in Kidney Size during Pathophysiological Intervention
Thomas Gladytz1, Ehsan Tasbihi1, Jason M. Millward1, Kathleen Cantow2, Luis Hummel2, Joao S. Periquito1,2, Sonia Waiczies1, Erdmann Seeliger2, and Thoralf Niendorf1,3
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Institute of Physiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Experimental and Clinical Research Center, a joint cooperation between the Charité - Universitätsmedizin Berlin and the Max Delbrueck Center for Molecular Medicine, Berlin, Germany
Several renal pathologies are associated with changes in kidney size, offering an opportunity for magnetic resonance imaging (MRI) biomarkers of disease. An automated bean-shaped model was developed for kidney size measurements in rats using parametric MRI (T2, T2* mapping). The ABSM approach was applied to longitudinal renal size quantification during pathophysiologically relevant interventions affecting kidney size. A precision and accuracy similar to manual segmentation was achieved allowing size changes of 2% to be detected reliably. This can potentially be instrumental for developing MRI-based diagnostic tools for various kidney disorders and for gaining new insight into mechanisms of renal pathophysiology.
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