In this study, the effect of the electric potential of lipid vesicle surfaces on MR relaxation times and magnetization transfer was investigated. Negatively charged multilamellar vesicles were formed, and their surface potential was adjusted by changing the sodium ion concentration. While the zeta potential changed from -57.0 mV to –21.6 mV, T2 increased from 48.2 ms to 67.4 ms, PSR decreased from 5.5% to 5.0%, kmf decreased from 82.7 Hz to 40.6 Hz, and T2b increased from 177.8 μs to 189.1 μs. These observations are expected to be utilized to image action potential generated in white matter.
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