To find novel contrast mechanisms of neuronal activity, our group previously demonstrated using in vitro cells that changes in membrane potential induces changes in MR parameters. There are two plausible factors that may contribute when the membrane potential changes: the dynamics of hydration water, and cell swelling. In this study, we investigated if cell swelling can contribute to changes in T2 under a constant membrane potential using non-excitable cells. As a result, we found that cell swelling induces measurable changes. As the cell size increased, the short T2 component caused by the intracellular water increased and vice versa.
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