Abstract #1526

Iron, myelin and cortical brain ageing: investigating correlations between QSM, R2, R2* and R2'

Ana-Maria Oros-Peusquens¹, Luis Hau¹, and N. Jon Shah^1,2,3,4

¹Institute of Neuroscience and Medicine INM-4, Research Centre Juelich, Juelich, Germany, ²Department of Neurology, RWTH Aachen University, Aachen, Germany, ³Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany, ⁴Institute of Neuroscience and Medicine 11, INM-11, JARA, Research Centre Juelich, Juelich, Germany

Synopsis

Understanding MR contrast/relaxation in vivo based on myelin and iron content is an on-going endeavour. We study the age dependence and correlation of QSM, R2, R2’ and R2* in vivo with whole brain coverage, investigating whether the interplay between demyelination and iron increases explains changes in these four qMRI parameters. The observations suggest that age-related influences proceed mostly by the intra-cellular iron effect on QSM and demyelination effect on R2.

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