Iron, myelin and cortical brain ageing: investigating correlations between QSM, R2, R2* and R2'
Ana-Maria Oros-Peusquens1, Luis Hau1, and N. Jon Shah1,2,3,4
1Institute of Neuroscience and Medicine INM-4, Research Centre Juelich, Juelich, Germany, 2Department of Neurology, RWTH Aachen University, Aachen, Germany, 3Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany, 4Institute of Neuroscience and Medicine 11, INM-11, JARA, Research Centre Juelich, Juelich, Germany
Understanding MR contrast/relaxation in vivo based on myelin and iron content is an on-going endeavour. We study the age dependence and correlation of QSM, R2, R2’ and R2* in vivo with whole brain coverage, investigating whether the interplay between demyelination and iron increases explains changes in these four qMRI parameters. The observations suggest that age-related influences proceed mostly by the intra-cellular iron effect on QSM and demyelination effect on R2.
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