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Abstract #1527

MRI-based liver vascular morphology and surface nodularity quantification for assessment of portal hypertension

Yikun Wang1, Ruokun Li1, Jiahao Zhou1, Chengyan Wang2, and Fuhua Yan1
1Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, 2Human Phenome Institute, Fudan University, Shanghai, China


Hepatic venous pressure gradient (HVPG) measurement is the standard technique of assessing portal pressure. Portal hypertension is mainly caused by increased intrahepatic resistance to portal blood flow related to structural changes, including fibrosis and vascular distortion. Here, we used dynamic contrast-enhancement (DCE) MRI to quantify segmented liver contours and vascular morphology in evaluating portal pressure. Our study showed the MRI measurements correlated well with HVPG measurement. A non-invasive prediction model combining liver vascular morphology and liver surface nodularity (LSN) can potentially be used to assess clinically significant portal hypertension (CSPH).

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