R1ρ dispersion at weak locking fields (R1ρDiff) has the potential to reveal information on microvascular geometry and density. Our results show ΔR1ρ of white matter extracted from R1ρDiff dispersion is significantly greater in subjects with lower RBANS and MoCA scores. R2 or R1p values measured at a single locking field amplitude have no significant correlation with cognitive impairment scores. This work supports the hypothesis that microvascular impairment in white matter may be one of the causal factors in the progression of cognitive impairment in older adults.
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