T1ρ Dispersion in White Matter Correlates with Quantitative Metrics of Cognitive Impairment
Fatemeh Adelnia1,2, Taylor L Davis2, Lealani Mae Acosta3, Amanda Puckett3, Feng Wang1,2, Zhongliang Zu1,2, Kevin D Harkins1,2, and John C Gore1,2,4
1Vanderbilt University Institute of Imaging Science, NASHVILLE, TN, United States, 2Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, NASHVILLE, TN, United States, 3Department of Neurology, Vanderbilt University Medical Center, NASHVILLE, TN, United States, 4Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States
R1ρ dispersion at weak locking fields (R1ρDiff) has the potential to reveal information on microvascular geometry and density. Our results show ΔR1ρ of white matter extracted from R1ρDiff dispersion is significantly greater in subjects with lower RBANS and MoCA scores. R2 or R1p values measured at a single locking field amplitude have no significant correlation with cognitive impairment scores. This work supports the hypothesis that microvascular impairment in white matter may be one of the causal factors in the progression of cognitive impairment in older adults.
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