Abstract #1549

Sex-differences in CBF changes as a biomarker of preclinical MCI

Safa Sanami^1,2, Brittany N Intzandt^2,3,4, Julia Huck^1,2, PREVENT-AD Research Group⁵, and Claudine J Gauthier^1,2,4

¹Physics, Concordia University, Montreal, QC, Canada, ²PERFORM Centre, Concordia University, Montreal, QC, Canada, ³Centre de Recherche de l’Institut Universitaire de G´eriatrie de Montr´eal, Montreal, QC, Canada, ⁴Centre de Recherche de l’Institut de Cardiologie de Montr´eal, Montreal, QC, Canada, ⁵StoP-AD, Douglas Mental Health Institute, Montreal, QC, Canada

Synopsis

Alzheimer’s Disease (AD) is the most common form of dementia, preceded by a mild cognitive impairment (MCI) prodromal stage. There are sex differences in the prevalence and severity of MCI and AD. However, the presence of sex differences in cerebral hemodynamics during the transition from normal cognition to MCI is unknown. This is the first study to assess whether sex differences exist in cerebral blood flow (CBF) in the years prior to MCI diagnosis in patients with a familial history of AD.

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