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Abstract #1549

Sex-differences in CBF changes as a biomarker of preclinical MCI

Safa Sanami1,2, Brittany N Intzandt2,3,4, Julia Huck1,2, PREVENT-AD Research Group5, and Claudine J Gauthier1,2,4
1Physics, Concordia University, Montreal, QC, Canada, 2PERFORM Centre, Concordia University, Montreal, QC, Canada, 3Centre de Recherche de l’Institut Universitaire de G´eriatrie de Montr´eal, Montreal, QC, Canada, 4Centre de Recherche de l’Institut de Cardiologie de Montr´eal, Montreal, QC, Canada, 5StoP-AD, Douglas Mental Health Institute, Montreal, QC, Canada


Alzheimer’s Disease (AD) is the most common form of dementia, preceded by a mild cognitive impairment (MCI) prodromal stage. There are sex differences in the prevalence and severity of MCI and AD. However, the presence of sex differences in cerebral hemodynamics during the transition from normal cognition to MCI is unknown. This is the first study to assess whether sex differences exist in cerebral blood flow (CBF) in the years prior to MCI diagnosis in patients with a familial history of AD.

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