Abstract #1550
Post-traumatic stress disorder may affect the progression of cognitive impairment in World Trade Center responders
Juin W. Zhou1, Minos Kritikos2,3, Chuan Huang4,5, Sean A. P. Clouston2,3, Roberto G. Lucchini6, Samuel E. Gandy7,8, Benjamin J. Luft9,10, and Evelyn J. Bromet5
1Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2Program in Public Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, United States, 3Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, United States, 4Department of Radiology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, United States, 5Department of Psychiatry, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, United States, 6Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 7Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 8Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 9Stony Brook World Trade Center Wellness Program, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, United States, 10Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, United States
Synopsis
A larger than expected number of World Trade Center (WTC) responders, now at midlife, are experiencing chronic post-traumatic stress disorder (PTSD) and incidence of mild cognitive impairment (MCI). A previous study reported that WTC responders with MCI have altered white matter connectivity when compared to unimpaired responders. However, the effects of PTSD on fiber integrity in this population was not studied due to a limited sample size. In the present study, we analyzed 97 WTC responders with/without CI and/or PTSD. Our results suggest that PTSD may influence the neuropathology of CI within this population.
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