Abstract #1551
Multivariate quantification of brain differences in individuals with family history of Alzheimer's disease and APOE4 genetic risk
Stefanie A Tremblay1,2, Nathan Spreng3,4,5, Amir Pirhadi6, Julia Huck1, Christine Lucas Tardif7,8,9, Mallar Chakravarty10,11, PREVENT-AD Research Group12, Sylvia Villeneuve10,13,14,15, Ilana Ruth Leppert7,8,9, Felix Carbonell16, Yasser Iturria-Medina8,9,17, Christopher J Steele18,19, and Claudine J Gauthier1,2
1Physics, Concordia University, Montreal, QC, Canada, 2Montreal Heart Institute, Montreal, QC, Canada, 3Laboratory of Brain and Cognition, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 4McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 5Departments of Psychiatry and Psychology, McGill University, Montreal, QC, Canada, 6Electrical and Computer Engineering, Concordia University, Montreal, QC, Canada, 7Biomedical Engineering, McGill University, Montreal, QC, Canada, 8McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, 9Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 10StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montreal, QC, Canada, 11McGill University, Montreal, QC, Canada, 12StoP-AD Centre, Douglas Mental Health Institute, Montreal, QC, Canada, 13McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 14McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 15CRIUGM - Université de Montreal, Montreal, QC, Canada, 16Biospective Inc., Montreal, QC, Canada, 17Ludmer Centre for NeuroInformatics and Mental Health, Montreal, QC, Canada, 18Psychology, Concordia University, Montreal, QC, Canada, 19Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
Synopsis
Although the APOE4 genotype is known to increase the risk of developing Alzheimer’s disease (AD), the mechanisms through which this occurs are not fully understood. Here, we used a voxel-wise multivariate approach, the Mahalanobis distance (MhD), to quantify the extent to which the white matter microstructure of individuals with the APOE4 genotype differ from those without the E4 allele. The MhD of individuals with the E4 allele deviated significantly from our reference group in several regions, including tracts projecting to the hippocampus, a region known for its involvement in AD. Future work will investigate links with cognition and lifestyle factors.
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