The association between white matter hyperintensity shape and long-term dementia outcome in community-dwelling older adults
Jasmin A. Keller1, Sigurður Sigurdsson2, Kelly Klaassen1, Eveline Scholte1, Lydiane Hirschler1, Mark A. van Buchem1, Lenore J. Launer3, Matthias J.P. van Osch1, Vilmundor V. Gudnason2, and Jeroen de Bresser1
1Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Icelandic Heart Association, Kopavogur, Iceland, 3Laboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD, United States
Recently white matter hyperintensity (WMH) shape was introduced as a promising novel marker that may provide a more detailed characterization of WMH than volume alone. We aimed to investigate the association between WMH shape and the occurrence of dementia later in life in community dwelling older adults. WMH shape markers and WMH volumes were determined for periventricular/confluent, and deep WMH. A more complex shape of periventricular/confluent WMH (higher fractal dimension), as well as total and periventricular/confluent WMH volume, were associated with a greater risk of dementia. These results may indicate a prognostic value of WMH shape markers.
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