The Patlak model is commonly applied to brain DCE-MRI to quantify subtle blood-brain barrier permeability. This is based on existing evidence showing the Patlak model provides the optimal fit compared to other candidate models, including the extended Tofts model (Heye, Thrippleton et al. 2016). In this study, we compared five different tracer kinetic models in data with higher temporal resolution and determined that models which assume finite interstitial volume (ve) (e.g. extended Tofts) consistently outperform models that assume infinite ve (e.g. Patlak), particularly in gray matter.
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