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Abstract #1581

To what extent is DSC-MRI able to detect subtle blood-brain barrier leakage in cerebral small-vessel disease?

Elles Elschot1,2, Walter Backes1,2,3, Joost de Jong1,2, Gerhard Drenthen1,2, Sau May Wong1, Julie Staals3,4, Robert van Oostenbrugge2,3,4, Rob Rouhl4, and Jacobus Jansen1,2,5
1Radiology and Nuclear Medicine, Maastricht University Medical Center +, Maastricht, Netherlands, 2School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, 3CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands, 4Neurology, Maastricht University Medical Center +, Maastricht, Netherlands, 5Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands


This study investigated to what extent blood-brain barrier (BBB) leakage (1) can be measured with DSC-MRI and (2) is influenced by perfusion. In vivo DCE (golden-standard) and DSC data of patients with cerebral small vessel disease (cSVD) and elderly controls were used, as well as simulations of signal curves. DSC-MRI, in contrast to DCE-MRI, is not sensitive enough to measure subtle leakage in cSVD. Further research is required to better disentangle perfusion effects from leakage, and therefore correction methods should be used with caution for measuring subtle leakage.

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