Abstract #1581

To what extent is DSC-MRI able to detect subtle blood-brain barrier leakage in cerebral small-vessel disease?

Elles Elschot^1,2, Walter Backes^1,2,3, Joost de Jong^1,2, Gerhard Drenthen^1,2, Sau May Wong¹, Julie Staals^3,4, Robert van Oostenbrugge^2,3,4, Rob Rouhl⁴, and Jacobus Jansen^1,2,5

¹Radiology and Nuclear Medicine, Maastricht University Medical Center +, Maastricht, Netherlands, ²School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, ³CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands, ⁴Neurology, Maastricht University Medical Center +, Maastricht, Netherlands, ⁵Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

Synopsis

This study investigated to what extent blood-brain barrier (BBB) leakage (1) can be measured with DSC-MRI and (2) is influenced by perfusion. In vivo DCE (golden-standard) and DSC data of patients with cerebral small vessel disease (cSVD) and elderly controls were used, as well as simulations of signal curves. DSC-MRI, in contrast to DCE-MRI, is not sensitive enough to measure subtle leakage in cSVD. Further research is required to better disentangle perfusion effects from leakage, and therefore correction methods should be used with caution for measuring subtle leakage.

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