Abstract #1584

Comparison of arterial input functions obtained through back-to-back acquisition of DCE and DSC MRI

Chih-Hsien Tseng¹, Jaap Jaspers², Alejandra Mendez Romero², Piotr Wielopolski³, Matthias van Osch ⁴, and Frans Vos^1,3

¹Imaging Physics, Delft University of Technology, Delft, Netherlands, ²Radiation Oncology, Erasmus Medical Center, Rotterdam, Netherlands, ³Radiology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Radiology, Leiden University Medical Center, Leiden, Netherlands

Synopsis

We aimed to compare the AIF determined from DCE-MRI with the AIF from DSC-MRI in back-to-back imaging, using the same dose of Gadobutrol. The DCE-driven AIFs showed the same ‘pattern’ as the DSC-driven AIFs, but had smaller variance of the shape and peak value. A linear relation was found between the contrast agent concentration from DCE and ΔR₂*, but the linear coefficients showed large variation across regions and subjects. Our findings show that the DCE-driven AIF has the potential to serve as an alternative for the DSC-driven AIFs for quantitative perfusion assessment.

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