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Abstract #1584

Comparison of arterial input functions obtained through back-to-back acquisition of DCE and DSC MRI

Chih-Hsien Tseng1, Jaap Jaspers2, Alejandra Mendez Romero2, Piotr Wielopolski3, Matthias van Osch 4, and Frans Vos1,3
1Imaging Physics, Delft University of Technology, Delft, Netherlands, 2Radiation Oncology, Erasmus Medical Center, Rotterdam, Netherlands, 3Radiology, Erasmus Medical Center, Rotterdam, Netherlands, 4Radiology, Leiden University Medical Center, Leiden, Netherlands


We aimed to compare the AIF determined from DCE-MRI with the AIF from DSC-MRI in back-to-back imaging, using the same dose of Gadobutrol. The DCE-driven AIFs showed the same ‘pattern’ as the DSC-driven AIFs, but had smaller variance of the shape and peak value. A linear relation was found between the contrast agent concentration from DCE and ΔR2*, but the linear coefficients showed large variation across regions and subjects. Our findings show that the DCE-driven AIF has the potential to serve as an alternative for the DSC-driven AIFs for quantitative perfusion assessment.

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