Inter-reader variability in apparent diffusion coefficient measurements for assessment of breast cancer response to neoadjuvant therapy
Nu N. Le1, Wen Li1, Natsuko Onishi1, David Newitt1, Jessica Gibbs1, Lisa Wilmes1, John Kornak2, Savannah C. Partridge3, Elissa Price1, Bonnie N. Joe1, Laura Esserman2, and Nola M. Hylton1
1Radiology, UCSF, San Francisco, CA, United States, 2UCSF, San Francisco, CA, United States, 3University of Washington, Seattle, WA, United States
This study presents a retrospective analysis of inter-reader variability in tumor ADC measurements extracted from three types of ROIs using data from the multi-center I-SPY 2 trial. Overall, good agreement was observed between two readers. Mean ADCs measured in restricted ROIs were highly reproducible by manual delineation. Mean ADCs of multi-slice restricted ROIs showed higher ICCs than single-slice restricted ROIs.
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