Abstract #1590

Inter-reader variability in apparent diffusion coefficient measurements for assessment of breast cancer response to neoadjuvant therapy

Nu N. Le¹, Wen Li¹, Natsuko Onishi¹, David Newitt¹, Jessica Gibbs¹, Lisa Wilmes¹, John Kornak², Savannah C. Partridge³, Elissa Price¹, Bonnie N. Joe¹, Laura Esserman², and Nola M. Hylton¹

¹Radiology, UCSF, San Francisco, CA, United States, ²UCSF, San Francisco, CA, United States, ³University of Washington, Seattle, WA, United States

Synopsis

This study presents a retrospective analysis of inter-reader variability in tumor ADC measurements extracted from three types of ROIs using data from the multi-center I-SPY 2 trial. Overall, good agreement was observed between two readers. Mean ADCs measured in restricted ROIs were highly reproducible by manual delineation. Mean ADCs of multi-slice restricted ROIs showed higher ICCs than single-slice restricted ROIs.

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