Abstract #1591
Magnetic Resonance Elastography for Early Assessment of Response to Neoadjuvant Chemotherapy in Women with Breast Cancer
Patriek Jurrius1,2, Omar Darwish3,4,5, Daniel Fovargue3, Belul Shifa6, Karen Welsh7, Joanna Bell7, Sarah-Jane Hamilton7, John Spence7, Giacomo Annio4, Renee Miller3, Marian Troelstra3, Ashutosh Kothari2, Hisham Hamed2, Georgina Bitsakou2, Ali Sever8, Sultana Hasso8, Yasmin Giambrone8, Isaac Daimiel Naranjo8, Katerina Ntailiani8, Keshthra Satchithananda9, Sarah Willson8, Sarah Pinder1,10, Anne Rigg11, David Nordsletten3, Radhouene Neji3,5, Tony Ng1, Arnie Purushotham1,2, and Ralph Sinkus3,4
1School of Cancer & Pharmaceutical Sciences, King's College London, London, United Kingdom, 2Oncoplastic breast surgery, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom, 3School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 4Inserm U1148, LVTS, University Paris Diderot, Paris, France, 5MR Research Collaborations, Siemens Healthcare Ltd., Frimley, United Kingdom, 6Oncology and Haematology Clinical Trials, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom, 7MRI department, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom, 8Breast Radiology, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom, 9Breast Radiology, King's College Hospital NHS Foundation, London, United Kingdom, 10Histopathology, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom, 11Medical Oncology, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom
Synopsis
Approximately one-third of women with breast cancer undergoing neoadjuvant chemotherapy (NACT) have no discernible disease response to their treatment yet are subjected to the potential side-effects of their treatment. Currently, response to NACT is assessed by determining tumour size, contrast avidity, and lymph node involvement on MRI pre-, mid- and post-treatment. As a result, women undergo 3-4 cycles of NACT with unknown efficacy. Changes in a tumour’s biomechanics as assessed by magnetic resonance elastography (MRE) after only one cycle of NACT correlate with response to treatment, allowing for early assessment of a patient’s response to NACT.
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