Abstract #1591

Magnetic Resonance Elastography for Early Assessment of Response to Neoadjuvant Chemotherapy in Women with Breast Cancer

Patriek Jurrius^1,2, Omar Darwish^3,4,5, Daniel Fovargue³, Belul Shifa⁶, Karen Welsh⁷, Joanna Bell⁷, Sarah-Jane Hamilton⁷, John Spence⁷, Giacomo Annio⁴, Renee Miller³, Marian Troelstra³, Ashutosh Kothari², Hisham Hamed², Georgina Bitsakou², Ali Sever⁸, Sultana Hasso⁸, Yasmin Giambrone⁸, Isaac Daimiel Naranjo⁸, Katerina Ntailiani⁸, Keshthra Satchithananda⁹, Sarah Willson⁸, Sarah Pinder^1,10, Anne Rigg¹¹, David Nordsletten³, Radhouene Neji^3,5, Tony Ng¹, Arnie Purushotham^1,2, and Ralph Sinkus^3,4

¹School of Cancer & Pharmaceutical Sciences, King's College London, London, United Kingdom, ²Oncoplastic breast surgery, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom, ³School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, ⁴Inserm U1148, LVTS, University Paris Diderot, Paris, France, ⁵MR Research Collaborations, Siemens Healthcare Ltd., Frimley, United Kingdom, ⁶Oncology and Haematology Clinical Trials, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom, ⁷MRI department, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom, ⁸Breast Radiology, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom, ⁹Breast Radiology, King's College Hospital NHS Foundation, London, United Kingdom, ¹⁰Histopathology, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom, ¹¹Medical Oncology, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom

Synopsis

Approximately one-third of women with breast cancer undergoing neoadjuvant chemotherapy (NACT) have no discernible disease response to their treatment yet are subjected to the potential side-effects of their treatment. Currently, response to NACT is assessed by determining tumour size, contrast avidity, and lymph node involvement on MRI pre-, mid- and post-treatment. As a result, women undergo 3-4 cycles of NACT with unknown efficacy. Changes in a tumour’s biomechanics as assessed by magnetic resonance elastography (MRE) after only one cycle of NACT correlate with response to treatment, allowing for early assessment of a patient’s response to NACT.

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