Abstract #1592

Monitoring the response of breast tumors to neoadjuvant chemotherapy using multimodal magnetic resonance and optical imaging – a case study

Bin Deng^1,2,3, Ailis Muldoon^1,2, Pedro Itriago⁴, Wei-Ching Lo⁵, Mansi Saksena^2,3, Samuel Patz^3,6, Ralph Sinkus⁷, Steven J. Isakoff^3,8, and Stefan A. Carp^1,2,3

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Siemens Medical Solutions, Houston, TX, United States, ⁵Siemens Medical Solutions, Boston, MA, United States, ⁶Department of Radiology, Brigham and Women’s Hospital, Boston, MA, United States, ⁷Laboratory for Vascular Translational Science (LVTS), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France, ⁸Cancer Center, Massachusetts General Hospital, Boston, MA, United States

Synopsis

Functional imaging is advantageous in monitoring neoadjuvant chemotherapy (NACT) since changes in tumor physiology manifest earlier than actual tumor shrinkage. We leveraged a custom breast coil for multimodal T1, DWI, MRE, and near-infrared optical imaging to evaluate the response of breast tumors to NACT. In this case study of a patient who achieved pathologic complete response, concordant changes in tumor size, ADC, stiffness and total hemoglobin concentration have been observed. This multiparametric approach could help us gain a comprehensive understanding of the multitude of simultaneous physiological changes in tumors related to microenvironment, angiogenesis, and metabolism as a result of NACT.

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