Abstract #1593

Predicting response to neoadjuvant therapy using tumor morphologic features on breast MRI

Wen Li¹, Rohan Nadkarni¹, David C Newitt¹, Natsuko Onishi¹, Jessica Gibbs¹, Lisa J Wilmes¹, Bonnie N Joe¹, Efstathios D Gennates², John Kornak², Mark Magbanua³, Laura van't Veer³, Barbara LeStage⁴, I-SPY 2 Consortium⁵, Laura J Esserman⁶, and Nola M Hylton¹

¹Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, United States, ³Laboratory Medicine, University of California, San Francisco, San Francisco, CA, United States, ⁴I-SPY 2 Advocacy Group, San Francisco, CA, United States, ⁵Quantum Leap Healthcare Collaborative, San Francisco, CA, United States, ⁶Surgery, University of California, San Francisco, San Francisco, CA, United States

Synopsis

Functional tumor volume (FTV) has been used to longitudinally assess tumor response to neoadjuvant therapy longitudinally in I-SPY trials. Previously, we found that a single 3D shape feature, sphericity, is associated with pathologic complete response (pCR). In this study, we expanded the analysis by including all radiomic shape features in an elastic net model and evaluated their role in prediction of pCR in the multi-center I-SPY 2 trial. Our results showed that the model with shape features outperformed the models with FTV or sphericity alone.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.