Solid-state MR based quantitative assessment of bone water and 31P differentiates between postmenopausal women with and without osteoporosis
Brandon Clinton Jones1,2, Cheng-Chieh Cheng1,3, Xia Zhao1, Hyunyeol Lee1,4, Mona Al Mukaddam5, Peter J Snyder5, Chamith S Rajapakse1, Hee Kwon Song1, and Felix W Wehrli1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 3Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan, 4School of Electronics, Kyungpook National University, Daegu, Korea, Republic of, 5Department of Endocrinology, University of Pennsylvania, Philadelphia, PA, United States
Fifteen osteoporotic, treatment-naïve, and 19 non-osteoporotic postmenopausal women have been examined in an ongoing study to evaluate tibial cortical bone health via solid-state MRI. Proton dual-echo UTE and IR-prepared rapid-UTE sequences were used for quantification of pore and bound water concentrations, and a 31P PETRA-ZTE sequence for quantification of bone mineralization. Osteoporotics showed elevated pore and total water concentration, thinner cortices, decreased 31P content and degree of bone mineralization (DBM). Our preliminary results suggest that solid-state MR biomarkers of bone porosity and DBM may be useful in evaluating cortical bone health.
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