Fifteen osteoporotic, treatment-naïve, and 19 non-osteoporotic postmenopausal women have been examined in an ongoing study to evaluate tibial cortical bone health via solid-state MRI. Proton dual-echo UTE and IR-prepared rapid-UTE sequences were used for quantification of pore and bound water concentrations, and a 31P PETRA-ZTE sequence for quantification of bone mineralization. Osteoporotics showed elevated pore and total water concentration, thinner cortices, decreased 31P content and degree of bone mineralization (DBM). Our preliminary results suggest that solid-state MR biomarkers of bone porosity and DBM may be useful in evaluating cortical bone health.
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