Postmenopausal osteoporosis (PMOP) in the female elderly population has become one of serious health problems of the rapidly aging society in China. The aim of this work was to preliminary investigate the changes of bone marrow fatty acid composition in the presence of trabecular bone of PMOP and age-matched healthy controls (HC) using 2D intermolecular double-quantum coherence based magnetic resonance spectroscopy (iDQC-MRS). We found monounsaturated fatty acids (P < 0.001) and polyunsaturated fatty acids(p < 0.01) were significant higher lower in the PMOP group. The lower unsaturated fatty acids levels may play an important role in the pathogenesis of PMOP.
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