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Abstract #1598

IVIM Detects Bone Ischemia in a Piglet Model of Legg-Calvé-Perthes Disease

Erick Odoyo Buko1,2, Sampada Bhave1, Ferenc Tóth1, and Casey P Johnson1,2
1Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States


Intravoxel incoherent motion (IVIM) is a promising method to measure both tissue diffusion and perfusion using a single multi b-value diffusion-weighted imaging (DWI) acquisition. In this work, we investigated whether IVIM is sensitive in detecting surgically-induced femoral head ischemia in a piglet model of avascular necrosis. We found that the IVIM perfusion coefficient (Df) and fraction (f) decreased in the ischemic vs. contralateral-control femoral heads. Conversely, the IVIM diffusion coefficient (Ds) increased as a result of subsequent injury to the operated femoral head. These findings suggest that IVIM may provide a non-contrast-enhanced means to assess bone ischemia and perfusion.

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