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Abstract #1599

Comprehensive Assessment of Osteoporosis in Lumbar Spine Using Compositional MR Imaging of Trabecular Bone

Jin Liu1, Jian-Wei Liao1, Jia-Xin Feng1, Wei Li1, Xiao-Jun Chen1, Lin Yao1, Pan-Hui Huang1, Long Qian2, Ya-Jun Ma3, and Shao-Lin Li1
1Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China, 2MR Research, GE Healthcare, Beijing, China, 3Department of Radiology, University of California San Diego, San Diego, CA, United States


Compositional MR Imaging, which is combined of a Short TR Adiabatic Inversion Recovery prepared Ultrashort Echo Time (STAIR-UTE) and the Iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL-IQ) techniques, is developed to measure collagen bound water proton fraction, free water proton fraction, total water proton fraction of trabecular bone in lumbar spine. These biomarkers are highly correlated with bone mineral density, T score and Fracture Risk Assessment Tool scores, which demonstrates that the compositional MR imaging has great potential in diagnosis of patient with osteoporosis.

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