Compositional MR Imaging, which is combined of a Short TR Adiabatic Inversion Recovery prepared Ultrashort Echo Time (STAIR-UTE) and the Iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL-IQ) techniques, is developed to measure collagen bound water proton fraction, free water proton fraction, total water proton fraction of trabecular bone in lumbar spine. These biomarkers are highly correlated with bone mineral density, T score and Fracture Risk Assessment Tool scores, which demonstrates that the compositional MR imaging has great potential in diagnosis of patient with osteoporosis.
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