Quantitative MR of the Distal Radius Bone Marrow as a marker of Osteoporosis
Tamar K. De-Levie1,2, Yael S. Schiffenbauer1, Ido Druckmann3, Vanessa Rouach4, Naftali Stern2,4,5,6, Itzhak Binderman7, and Uri Nevo1,5
1Department of Biomedical Engineering, Tel Aviv University, Tel-Aviv, Israel, 2Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel, 3Skeletal Imaging Division, Tel Aviv-Sourasky Medical Center, Tel-Aviv, Israel, 4Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Tel-Aviv, Israel, 5The Sagol School of Neuroscience, Tel Aviv University, Tel-Aviv, Israel, 6The Sagol Center for Epigenetics, Tel Aviv-Sourasky Medical Center, Tel-Aviv, Israel, 7Department of Oral Biology, School of Dental Medicine, Tel Aviv University, Tal-Aviv, Israel
In-vivo detection of osteoporosis-related changes in the distal radius bone marrow, using MR protocols, could provide safe and accessible means for screening and monitoring. A clinical trial was performed, including 26 women assigned into three study groups: healthy premenopausal (n=7), healthy postmenopausal (n=10) and osteoporotic postmenopausal (n=9). Fat composition was evaluated using T2 maps, two-compartment model of T1 and Dixon sequence. The osteoporotic group exhibited higher fat content and lower T2 values compared to the healthy premenopausal group. This study provides proof of concept for the use of the distal radius bone marrow as probing site for osteoporosis.
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