In-vivo detection of osteoporosis-related changes in the distal radius bone marrow, using MR protocols, could provide safe and accessible means for screening and monitoring. A clinical trial was performed, including 26 women assigned into three study groups: healthy premenopausal (n=7), healthy postmenopausal (n=10) and osteoporotic postmenopausal (n=9). Fat composition was evaluated using T2 maps, two-compartment model of T1 and Dixon sequence. The osteoporotic group exhibited higher fat content and lower T2 values compared to the healthy premenopausal group. This study provides proof of concept for the use of the distal radius bone marrow as probing site for osteoporosis.
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