T1ρ has been investigated as a quantitative biomarker sensitive to changes in macromolecules such as proteoglycan and collagen in musculoskeletal systems. More recently, adiabatic T1ρ (Adiab-T1ρ) has emerged as an alternative to conventional continuous wave T1ρ to reduce the magic angle effect, which is a major confounding factor in accurate T1ρ estimation. In this study, we investigated a new pulse sequence combining adiabatic T1ρ preparation and efficient 3D fast spin echo (FSE) for more robust adiab-T1ρ mapping in the human knee. The efficacies of RF cycling and magnetization reset were also demonstrated.
This abstract and the presentation materials are available to members only; a login is required.