Abstract #1626

Pulse-width modulation for simultaneous concomitant field compensation and diffusion weighting in double diffusion encoding

Julian Rauch^1,2, Frederik B. Laun³, Dominik Ludwig¹, Maxim Zaitsev^4,5, Mark E. Ladd^1,2,6, Peter Bachert^1,2, and Tristan A. Kuder¹

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, ³Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁴Medical Physics, Department of Radiology, Faculty of Medicine, Medical Center University of Freiburg, Freiburg, Germany, ⁵High Field Magnetic Resonance Center, Center for Medical Physics and Biomedical Engineering Medical University of Vienna, Vienna, Austria, ⁶Faculty of Medicine, Heidelberg University, Heidelberg, Germany

Synopsis

Intravoxel dephasing caused by Maxwell or concomitant fields can lead to image artifacts as signal voids or falsify the quantitation. In this study, a framework for compensation of concomitant field effects for double diffusion encoding sequences with single pairs of bipolar gradients on each axis is presented. Using pulse-width modulated oscillating gradients with an optimized timing of the oscillating lobes allows for simultaneous diffusion weighting and compensation of the self-squared terms of the concomitant fields as well as for the cross terms. Simulations with realistic parameters reveal the possibility of a signal gain with the proposed method without significant drawbacks.

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