Apparent diffusion coefficient (ADC) metric is evaluated as a potential alternative to biopsy for disease grading and therapy response assessment in bone marrow of myelofibrosis (MF) patients. Spatially dependent bias in diffusion weighting due to systematic gradient nonlinearity (GNL) results in false heterogeneity of ADC maps over the imaged bone space. Here we illustrate deployment of prospective GNL bias correction based on technology developed in an academic industrial partnership to reduce technical variability of ADC in a MF clinical imaging trial.
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