Abstract #1634

Associations of Aging- and AD-associated 7T MRS Neurochemical Profiles with Cognition and Polygenic Risk for AD

Michael Wolf¹, Carlos Cruchaga², Jillilan Crocker¹, Priyanka Gorijala², Laura Hemmy³, James Hodges¹, Samira Mafimoghaddam², Silvia Mangia¹, Malgorzata Marjanska¹, Riley McCarten³, Thomas Nichols⁴, Jeromy Thotland¹, Rachel Zilinskas¹, and Melissa Terpstra⁵

¹University of Minnesota, Minneapolis, MN, United States, ²Washington University School of Medicine, St. Louis, MO, United States, ³Minneapolis VA Health Care System, Minneapolis, MN, United States, ⁴University of Oxford, Oxford, United Kingdom, ⁵University of Missouri, Columbia, MO, United States

Synopsis

Ultra-high field (7T) ultra-short echo time (8 ms STEAM) MRS can consistently provide a 14-neurochemical profile and distinguish aging and AD status. In this project, we generated composite scores from published age- and AD- specific neurochemical profiles and applied them to a typically aging cohort for whom polygenic risk for AD and extensive cognitive performance data were also available. Principal component analysis of the neurochemical profile fully distinguished aging, and AD classification was 58% correct. The largest correlation coefficients (r) were found between MRS and cognition. Correlation between MRS and polygenic risk and between cognition and polygenic risk was smaller.

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