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Abstract #1634

Associations of Aging- and AD-associated 7T MRS Neurochemical Profiles with Cognition and Polygenic Risk for AD

Michael Wolf1, Carlos Cruchaga2, Jillilan Crocker1, Priyanka Gorijala2, Laura Hemmy3, James Hodges1, Samira Mafimoghaddam2, Silvia Mangia1, Malgorzata Marjanska1, Riley McCarten3, Thomas Nichols4, Jeromy Thotland1, Rachel Zilinskas1, and Melissa Terpstra5
1University of Minnesota, Minneapolis, MN, United States, 2Washington University School of Medicine, St. Louis, MO, United States, 3Minneapolis VA Health Care System, Minneapolis, MN, United States, 4University of Oxford, Oxford, United Kingdom, 5University of Missouri, Columbia, MO, United States


Ultra-high field (7T) ultra-short echo time (8 ms STEAM) MRS can consistently provide a 14-neurochemical profile and distinguish aging and AD status. In this project, we generated composite scores from published age- and AD- specific neurochemical profiles and applied them to a typically aging cohort for whom polygenic risk for AD and extensive cognitive performance data were also available. Principal component analysis of the neurochemical profile fully distinguished aging, and AD classification was 58% correct. The largest correlation coefficients (r) were found between MRS and cognition. Correlation between MRS and polygenic risk and between cognition and polygenic risk was smaller.

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