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Abstract #1633

Age-related decline of glutathione: a magnetic resonance spectroscopy study in 180 elderly participants

Lars Michels1, Valerie Treyer2,3, Anton Gietl4, and Ruth O’Gorman Tuura5
1Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland, 2Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland, 3Institute of Regenerative Medicine Zurich, University of Zurich, Zurich, Switzerland, 4Institute of Regenerative Medicine Zurich., University of Zurich, Zurich, Switzerland, 5Center for MR Research, University Children's Hospital, Zurich, Switzerland


Glutathione (GSH) is a brain marker for oxidative stress, which has previously been associated with brain amyloidosis and memory decline. However, to date no study has examined the link between GSH and beta-amyloid in a large cohort of elderly participants. Using simultaneous PET/MRS, we assessed amyloid deposition with amyloid-PET and GSH with MEGAPRESS, in a cohort of 134 healthy elderly and 46 mild cognitively impaired participants. GSH declined with age and showed sex differences, but no significant association between GSH and amyloid status was observed

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