Abstract #1633

Age-related decline of glutathione: a magnetic resonance spectroscopy study in 180 elderly participants

Lars Michels¹, Valerie Treyer^2,3, Anton Gietl⁴, and Ruth O’Gorman Tuura⁵

¹Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland, ²Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland, ³Institute of Regenerative Medicine Zurich, University of Zurich, Zurich, Switzerland, ⁴Institute of Regenerative Medicine Zurich., University of Zurich, Zurich, Switzerland, ⁵Center for MR Research, University Children's Hospital, Zurich, Switzerland

Synopsis

Glutathione (GSH) is a brain marker for oxidative stress, which has previously been associated with brain amyloidosis and memory decline. However, to date no study has examined the link between GSH and beta-amyloid in a large cohort of elderly participants. Using simultaneous PET/MRS, we assessed amyloid deposition with amyloid-PET and GSH with MEGAPRESS, in a cohort of 134 healthy elderly and 46 mild cognitively impaired participants. GSH declined with age and showed sex differences, but no significant association between GSH and amyloid status was observed

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