Abstract #1632

In vivo CEST imaging of Glutamate and myo-Inositol for early-stage changes in Alzheimer’s 5xFAD mouse model

Ravi Prakash Reddy Nanga¹, Halvor Juul¹, Narayan Data Soni¹, Blake Benyard¹, Anshuman Swain², Ryan Armbruster¹, Paul Jacobs¹, and Ravinder Reddy¹

¹Radiology, Center for Advance Metabolic Imaging in Precision Medicine, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, ²Center for Advance Metabolic Imaging in Precision Medicine, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States

Synopsis

In order to probe the metabolism of glutamate and myo-inositol for better understanding of the Alzheimer’s diseases (AD) we have employed the chemical exchange saturation transfer of glutamate (GluCEST) and myoinositol (MICEST) in a fast progressing, 5xFAD mouse model. There were significant differences observed in the GluCEST and MICEST maps of 5XFAD mice when compared to the wild-type (WT) mice for regions of interest drawn on hippocampus and thalamus, which are further supported by the spectroscopy results.

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