In vivo CEST imaging of Glutamate and myo-Inositol for early-stage changes in Alzheimer’s 5xFAD mouse model
Ravi Prakash Reddy Nanga1, Halvor Juul1, Narayan Data Soni1, Blake Benyard1, Anshuman Swain2, Ryan Armbruster1, Paul Jacobs1, and Ravinder Reddy1
1Radiology, Center for Advance Metabolic Imaging in Precision Medicine, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, 2Center for Advance Metabolic Imaging in Precision Medicine, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States
In order to probe the metabolism of glutamate and myo-inositol for better understanding of the Alzheimer’s diseases (AD) we have employed the chemical exchange saturation transfer of glutamate (GluCEST) and myoinositol (MICEST) in a fast progressing, 5xFAD mouse model. There were significant differences observed in the GluCEST and MICEST maps of 5XFAD mice when compared to the wild-type (WT) mice for regions of interest drawn on hippocampus and thalamus, which are further supported by the spectroscopy results.
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