The apparent transverse relaxation rate ($$$R_{2}^{*}$$$) is influenced by biological features, e.g. iron and myelin content. However confounding factors, such as flip angle (α) and fibre orientation dependence, hinder interpretation. Multi-α data acquired as part of a comprehensive multi-parameter mapping approach can be used to mitigate these confounds. Here we explored how best to do so in vivo at 7T while additionally considering reproducibility. The ESTATICS approach, which assumes a common decay across flip angles, reduced these dependencies. $$$\hat{R_{2}^{*}}$$$, the α-independent component of a heuristic linear model, reduced both dependencies further but was less reproducible than ESTATICS.
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