We investigated the dependence of local frequency difference Δf and R2* on the fiber orientation with respect to the static field in selected parallel-fiber and crossing-fiber regions at 3T and 7T. Δf and R2* showed consistent relationship (sin2θ and sin4θ ) with average ROI-based fiber-to-field angle θ at 3T and 7T. Larger amplitude of variations in Δf and R2* with respect to θ were observed in parallel-fiber compared with crossing-fiber regions indicating non-negligible contributions from fiber orientation dispersion to the nonlinear gradient echo signal evolution and related MRI measures sensitive to white matter microstructure.
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