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Abstract #1643

Orientation dependence of local frequency difference and R2* in parallel versus crossing fibers at 3T and 7T

Lin Chen1,2, Deng Mao2, Guillaume Gilbert3, Maarten Versluis4, Peter van Zijl1,2, and Xu Li1,2
1Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3MR Clinical Science, Philips Canada, Mississauga, ON, Canada, 4MRI Clinical Scientist Neuroscience, Philips Healthcare, Best, Netherlands


We investigated the dependence of local frequency difference Δf and R2* on the fiber orientation with respect to the static field in selected parallel-fiber and crossing-fiber regions at 3T and 7T. Δf and R2* showed consistent relationship (sin2θ and sin4θ ) with average ROI-based fiber-to-field angle θ at 3T and 7T. Larger amplitude of variations in Δf and R2* with respect to θ were observed in parallel-fiber compared with crossing-fiber regions indicating non-negligible contributions from fiber orientation dispersion to the nonlinear gradient echo signal evolution and related MRI measures sensitive to white matter microstructure.

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