Abstract #1661

Texture Analysis Identifies Significant Pattern Differences in Pediatric Heart Transplant Recipients with and without Acute Rejection

Margaret Samyn¹, Ke Yan², Kristen George-Durrett³, Justin Godown³, Kimberly Crum³, Maryanne Christ⁴, Kak-Chen Chan⁴, Kak-Chen Chan⁴, David Bearl³, Debra Dodd³, Lazaro Hernandez⁴, Jonathan Soslow³, and Bruce Damon⁵

¹Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States, ²Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States, ³Pediatrics, Division of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Pediatric Cardiology, Joe DiMaggio Children’s Hospital at Memorial Healthcare System, Hollywood, FL, United States, ⁵Stephens Family Clinical Research Institute Carle Foundation Hospital, Urbana, IL, United States

Synopsis

Acute rejection (AR) continues to cause significant morbidity and mortality in pediatric heart transplant recipients (PHTx). Endomyocardial biopsy is the standard-of-care for diagnosis of AR, but it is invasive and associated with morbidity and mortality and can miss patchy AR. Cardiac magnetic resonance (CMR) was performed using parametric mapping and novel texture analysis to detect patterns of myocardial edema and fibrosis. Patients with AR had significant differences in texture analysis compared with patients without AR. CMR with texture analysis has potential as a non-invasive method for detection of AR in PHTx.

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