Texture Analysis Identifies Significant Pattern Differences in Pediatric Heart Transplant Recipients with and without Acute Rejection
Margaret Samyn1, Ke Yan2, Kristen George-Durrett3, Justin Godown3, Kimberly Crum3, Maryanne Christ4, Kak-Chen Chan4, Kak-Chen Chan4, David Bearl3, Debra Dodd3, Lazaro Hernandez4, Jonathan Soslow3, and Bruce Damon5
1Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States, 2Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States, 3Pediatrics, Division of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN, United States, 4Pediatric Cardiology, Joe DiMaggio Children’s Hospital at Memorial Healthcare System, Hollywood, FL, United States, 5Stephens Family Clinical Research Institute Carle Foundation Hospital, Urbana, IL, United States
Acute rejection (AR) continues to cause significant morbidity and mortality in pediatric heart transplant recipients (PHTx). Endomyocardial biopsy is the standard-of-care for diagnosis of AR, but it is invasive and associated with morbidity and mortality and can miss patchy AR. Cardiac magnetic resonance (CMR) was performed using parametric mapping and novel texture analysis to detect patterns of myocardial edema and fibrosis. Patients with AR had significant differences in texture analysis compared with patients without AR. CMR with texture analysis has potential as a non-invasive method for detection of AR in PHTx.
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