In Vivo Clinical Cardiac DTI in 5 minutes
Irvin Teh1, Christopher Kelly1, David Shelley2, Ana-Maria Poenar1, Sven Plein1, Erica Dall'Armellina1, Christopher Nguyen3,4, and Jürgen E. Schneider1
1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 2Leeds Teaching Hospitals Trust, Leeds, United Kingdom, 3Massachusetts General Hospital, Harvard Medical School, Cardiovascular Research Center, Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 4Health Science Technology, Harvard-MIT, Cambridge, MA, United States
There is strong interest in characterising the cardiac microstructure using in vivo cardiac diffusion tensor imaging (CDTI). However, its use in larger clinical studies is often hampered by long scan times. We sought to rationalise the scan parameters needed for a clinically feasible CDTI protocol, by comparing carefully subsampled data against a 24-minute reference dataset. A design strategy was identified based on maximising the number of diffusion-weighting (DW) directions, subject to minimum SNR requirements. Feasibility of a 5-minute protocol was demonstrated where NRMSE(MD) = 5.2±0.2%, NRMSE(FA) = 12.8±0.2%, RMSE(HA) = 5.5±0.4°, RMSE(absE2A) = 15.7±1.9°.
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