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Abstract #1670

The relationship between cardiac fiber structure and regional function after myocardial infarction in rats

Bård Andre Bendiksen1,2,3, Einar Sjaastad Nordén1,2,3, Ivar Sjaastad1,2, Lili Zhang1,2, and Emil Knut Stenersen Espe1,2
1Institute for Experimental Medical Research, University of Oslo and Oslo University Hospital, Oslo, Norway, 2KG Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway, 3Oslo New University College, Oslo, Norway


Little is known about the relationship between cardiac function and myocardial fiber structure after myocardial infarction (MI). We hypothesized that post-MI remodeling of left ventricular fiber structure would be reflected in changes in the regional strains. Strains and cardiac fiber structure were measured using MRI in five rats with MI, and three sham-operated rats. Transmural variation in fiber helix angles was reduced adjacent to the infarct. This reduction was associated with reduced radial, longitudinal, and endocardial circumferential strain, and improved epicardial circumferential strain in the adjacent zone. Our findings emphasize the relevance of cardiac fiber structure remodeling after myocardial infarction.

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