Abstract #1671

Vascular supply affects hemodynamic responses to a hypercapnia cerebrovascular reactivity challenge assessed by BOLD-fMRI

Kayley Marchena-Romero^1,2, Xiang Ji², Andrew Centen², Rosa Sommer^2,3, Joel Ramirez², Michael J Thrippleton⁴, Andrew Lim^2,3, Joanna M Wardlaw⁴, Sandra E Black², and Bradley J MacIntosh^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Sunnybrook Research Institute, Toronto, ON, Canada, ³Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, ⁴Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom

Synopsis

Cerebrovascular reactivity (CVR) is a dynamic assessment of hemodynamic response during hypercapnia. Conventional CVR metrics provide a single estimate to summarize the dilatory response to CO₂. We propose to isolate dilation and constriction responses to a CVR challenge measured by BOLD-fMRI and assess the effect of vascular supply on vasoreactivity. We show that vascular supply affects the hemodynamic response to hypercapnia, and that this effect varies over time in different clinical cohorts. This work suggests that the extraction of individual features embedded in a CVR challenge can help characterize cerebrovascular physiology in unique clinical cohorts.

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