Cerebrovascular reactivity (CVR) is a dynamic assessment of hemodynamic response during hypercapnia. Conventional CVR metrics provide a single estimate to summarize the dilatory response to CO2. We propose to isolate dilation and constriction responses to a CVR challenge measured by BOLD-fMRI and assess the effect of vascular supply on vasoreactivity. We show that vascular supply affects the hemodynamic response to hypercapnia, and that this effect varies over time in different clinical cohorts. This work suggests that the extraction of individual features embedded in a CVR challenge can help characterize cerebrovascular physiology in unique clinical cohorts.
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