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Abstract #1672

Repeatability of cerebrovascular reactivity amplitude and timing estimates using a sinusoidal manipulation of end-tidal CO2

Rachael C Stickland1, Kristina M Zvolanek1,2, and Molly G Bright1,2
1Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 2Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, United States


We assessed the repeatability of fMRI Cerebrovascular Reactivity (CVR) estimates using CO2 sinusoidal stimuli. We estimated BOLD-CVR amplitude and phase using a fast Fourier transform (FFT) analysis and a cross-correlation analysis (Rapidtide). Amplitude and delay maps showed sensible regional variations for both time-points, but participant variability was notable. CVR spatial correlations between time-points were higher after averaging within cortical parcels, compared to weak voxel-wise correlations. Qualitatively, Rapidtide achieved higher between-session correlations than FFT. GM average amplitudes agreed between time-points. At the correct spatial scale, with careful consideration of parameter scaling, this short stimulus is a viable CVR mapping option.

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