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Abstract #1673

Respiration volume per time (RVT) as a surrogate for end-tidal CO2 to map hemodynamic lag with BOLD fMRI

Kristina M. Zvolanek1,2, Stefano Moia3, Rachael C. Stickland1, César Caballero-Gaudes3, and Molly G. Bright1,2
1Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, 2Biomedical Engineering, Northwestern University, Evanston, IL, United States, 3Basque Center on Cognition, Brain and Language, Donostia, [Gipuzkoa], Spain


Using a breath-hold task to modulate end-tidal CO2 during a BOLD fMRI scan is an established method to map hemodynamic lag. However, end-tidal CO2 measurements may not be reliable in less compliant subjects and require additional monitoring equipment. We investigated whether a related metric, respiration volume per time (RVT) can be used as a surrogate for end-tidal CO2 by directly comparing the lag values derived from each physiological measurement. Similar spatial variation was observed in healthy adult participants, albeit with some degree of proportional bias, indicating respiration belt data can be used as an alternative to map hemodynamic lag.

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