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Abstract #1678

Improving measures of cerebrovascular reactivity using a sinusoidal hypercapnic challenge and dual-echo pseudocontinuous ASL

Colette Clare Milbourn1 and Nicholas Paul Blockley2
1School of Life Sciences, University of Nottingham, Nottingham, United Kingdom, 2The School of Life Sciences, University of Nottingham, Nottingham, United Kingdom


New clinical tools are needed for the diagnosis and prognosis of cerebrovascular diseases. Cerebrovascular Reactivity (CVR) is a potential marker for brain health and can be induced using stressors to the brain like high carbon dioxide (hypercapnia) challenges. These challenges can be used to map CVR. Dual-echo pseudocontinuous Arterial Spin Labelling (pCASL) and Blood Oxygen Level Dependent (BOLD) weighted imaging was combined with sinusoidally modulated and conventional block hypercapnic challenges to map CVR. Preliminary results show qualtitative improvements to pCASL based CVR maps when using sinusoidal hypercapnic challenges compared with the conventional block.

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