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Abstract #1679

Discrimination Between Benign and Malignant Lesions in the Breast with Restriction Spectrum Imaging on a Screening Breast MRI Cohort

Stephane Loubrie1, Ana Rodriguez-Soto1, Lauren Fang1, Christopher Conlin1, Maren MS Andreassen2, Tyler Seibert1,3,4, Michael Hahn1, Vandana Dialani5,6, Catherine J Wei7, Zahra Karimi5, Joshua Kuperman1, Anders Dale1,8, Etta Pisano5,9, and Rebecca Rakow-Penner1,4
1Radiology, UCSD, San Diego, CA, United States, 2Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, 3Radiation medecine, UCSD, San Diego, CA, United States, 4Bioengineering, UCSD, San Diego, CA, United States, 5Beth Israel Hospital, Boston, MA, United States, 6Harvard Medical School, Bosston, MA, United States, 7Commonwealth Radiology Associates, Boston, MA, United States, 8Neurosciences, UCSD, San Diego, CA, United States, 9American college of radiology, Reston, VA, United States


Diffusion weighted imaging (DWI) holds great potential in improving specificity of findings detected on contrast enhanced breast MRI. Restriction spectrum imaging (RSI), an advanced diffusion imaging model, has potential in discriminating between malignant and fibroglandular breast tissue. In this abstract, we evaluate RSI’s performance in differentiating malignant from benign lesions in a prospective study performed on a breast screening population. All lesions were biopsy proven. The breast RSI model allowed discrimination between malignant, high-risk and low-risk benign lesions and healthy fibroglandular tissue.

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