Abstract #1680

In vivo mapping of sodium relaxation times in breast fibroadenoma at 7T

Carlotta Ianniello^1,2, Ryan Brown^1,2, Linda Moy^1,2,3, Justin Fogarty¹, Freya Schnabel^3,4, Deborah Axelrod^3,4, and Guillaume Madelin^1,2

¹Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, United States, ⁴Department of Surgery, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Sodium (²³Na) MRI has been employed to measure the total sodium concentration (TSC) in breast lesions, which is often elevated compared to healthy breast. The knowledge of the ²³Na relaxation times of the breast, which could be subject to variations in lesions, could increase the accuracy of TSC estimation. In this work we measured the ²³Na relaxation times in six fibroadenoma patients and found a 71% increase in T_2,sand a 28% decrease in T₁ in the lesions compared to healthy tissue. Therefore, using healthy breast relaxation times in TSC quantification could result in errors in lesions.

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