Sodium Breast Imaging of Ductal Carcinomas at 3 T
Joshua D Kaggie1, Gabrielle C Baxter1, Mary A McLean1,2, Ramona Woitek1, Ferdia A Gallagher1,2, Andrew D James3,4, Aneurin J Kennerley4,5, Rolf F Schulte6, William J Brackenbury3,5, and Fiona J Gilbert1
1Radiology, University of Cambridge, Cambridge, United Kingdom, 2Cambridge Institute, Cancer Research UK, Cambridge, United Kingdom, 3Biology, University of York, York, United Kingdom, 4York Biomedical Research Institute, University of York, York, United Kingdom, 5Chemistry, University of York, York, United Kingdom, 6GE Healthcare, Munich, Germany
Sodium (23Na)-MRI was performed using a dual-tuned bilateral 23Na/1H breast coil on seven patients with ductal carcinoma, one patient with lobular carcinoma, and ten normal volunteers. Several patients had [23Na] measurements that were 2-3 times higher than the mean normal fibroglandular [23Na] measurements. There were no strong correlations between 23Na-MRI and either DCE or DWI measurements in the patients. These measurements suggest that [23Na] may provide an additional physiological imaging mechanism of breast cancer.
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