Abstract #1684

Sodium Breast Imaging of Ductal Carcinomas at 3 T

Joshua D Kaggie¹, Gabrielle C Baxter¹, Mary A McLean^1,2, Ramona Woitek¹, Ferdia A Gallagher^1,2, Andrew D James^3,4, Aneurin J Kennerley^4,5, Rolf F Schulte⁶, William J Brackenbury^3,5, and Fiona J Gilbert¹

¹Radiology, University of Cambridge, Cambridge, United Kingdom, ²Cambridge Institute, Cancer Research UK, Cambridge, United Kingdom, ³Biology, University of York, York, United Kingdom, ⁴York Biomedical Research Institute, University of York, York, United Kingdom, ⁵Chemistry, University of York, York, United Kingdom, ⁶GE Healthcare, Munich, Germany

Synopsis

Sodium (²³Na)-MRI was performed using a dual-tuned bilateral ²³Na/¹H breast coil on seven patients with ductal carcinoma, one patient with lobular carcinoma, and ten normal volunteers. Several patients had [²³Na] measurements that were 2-3 times higher than the mean normal fibroglandular [²³Na] measurements. There were no strong correlations between ²³Na-MRI and either DCE or DWI measurements in the patients. These measurements suggest that [²³Na] may provide an additional physiological imaging mechanism of breast cancer.

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