Abstract #1685

Variability of ADC Estimates Between-Scanners from Whole Body Imaging is Dominated by Within-Scanner Variance

Alistair Lamb¹, Alan Bainbridge², Tom Parry³, Harriet Rogers⁴, Stuart A Taylor³, Hui Zhang⁵, and Anna Barnes⁶

¹Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, ²Department of Medical Physics and Biomedical Engineering, University College London Hospitals NHS Foundation Trust, London, United Kingdom, ³Centre for Medical Imaging, University College London, London, United Kingdom, ⁴Institute of Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, United Kingdom, ⁵Centre for Medical Image Computing, University College London, London, United Kingdom, ⁶King's Technology Evaluation Centre, King’s College London, London, United Kingdom

Synopsis

We investigate the reliability of Whole-Body Imaging ADC estimates from subjects tested and retested within- and between-scanners from different vendors with minimal differences in acquisition protocol and post-acquisition analysis. We show substantial within-subject variation in extracranial ADC estimates within- and between-scanners as measured by Limits of Agreement. We additionally show between-scan variability between scanners is dominated by between-scan variability within a scanner. Furthermore, averaging across subsequent within-scanner examinations does not substantially improve reliability of ADC estimates. We therefore conclude a post-acquisition method for reducing within-scanner variation is required to improve the reliability of ADC estimates.

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