Variability of ADC Estimates Between-Scanners from Whole Body Imaging is Dominated by Within-Scanner Variance
Alistair Lamb1, Alan Bainbridge2, Tom Parry3, Harriet Rogers4, Stuart A Taylor3, Hui Zhang5, and Anna Barnes6
1Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, 2Department of Medical Physics and Biomedical Engineering, University College London Hospitals NHS Foundation Trust, London, United Kingdom, 3Centre for Medical Imaging, University College London, London, United Kingdom, 4Institute of Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, United Kingdom, 5Centre for Medical Image Computing, University College London, London, United Kingdom, 6King's Technology Evaluation Centre, King’s College London, London, United Kingdom
We investigate the reliability of Whole-Body Imaging ADC estimates from subjects tested and retested within- and between-scanners from different vendors with minimal differences in acquisition protocol and post-acquisition analysis. We show substantial within-subject variation in extracranial ADC estimates within- and between-scanners as measured by Limits of Agreement. We additionally show between-scan variability between scanners is dominated by between-scan variability within a scanner. Furthermore, averaging across subsequent within-scanner examinations does not substantially improve reliability of ADC estimates. We therefore conclude a post-acquisition method for reducing within-scanner variation is required to improve the reliability of ADC estimates.
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