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Abstract #1701

Reproducibility of IVIM Quantification Across Diffusion Gradient Waveforms using Pseudo-Diffusion and Physical IVIM Signal Models

Gregory Simchick1,2 and Diego Hernando1,2
1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States


The intravoxel incoherent motion (IVIM) DWI signal has been shown to depend on both b-value and the first motion moment (M1). However, traditional pseudo-diffusion IVIM signal models only include b-value dependence. In this work, monopolar and 2D (b-M1) IVIM acquisitions were acquired using diffusion gradient waveforms with different maximum amplitudes to emulate different gradient hardware. From each acquisition, IVIM estimates were obtained by fitting pseudo-diffusion and physical (M1 dependent) IVIM signal models. Estimated IVIM parameters were compared across acquisitions. Reproducible physical IVIM estimates were obtained using 2D IVIM-DWI acquisitions, while pseudo-diffusion IVIM estimates obtained using monopolar acquisitions demonstrated poor reproducibility.

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