Sodium MR signal acquisition and image reconstruction are severely hampered by the fast relaxation properties of the sodium nuclei. Signal decay due to fast transverse relaxation during readout leads to loss of high frequency information and severe partial volume effects (e.g.signal spill over from CSF into GM). In this work, we apply a reconstruction framework including anatomical regularization and signal decay modeling and estimation to dual echo sodium data to three subjects to investigate its effect on cortical grey matter sodium quantification.
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