This study aimed to use quantitative susceptibility mapping (QSM) to systematically investigate iron content changes of gray matter (GM) nuclei in patients with long-term anterior circulation artery stenosis (ACAS) and posterior circulation artery stenosis (PCAS). The differences of iron-related susceptibility in GM nuclei, including bilateral caudate nucleus, putamen (PU), globus pallidus (GP), thalamus, substantia nigra (SN), red nucleus and dentate nucleus (DN) were explored in 25 ACAS and 25 PCAS patients. Compared with healthy controls, mean susceptibility of bilateral PU, GP, and SN in ACAS and PCAS patients, and of extra bilateral DN in PCAS patients were significantly increased.
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