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Abstract #1746

Brain iron deposition in patients with unilateral middle cerebral artery stenosis: an in vivo quantitative susceptibility mapping study

Huimin Mao1, Weiqiang Dou2, Xinyi Wang1, Kunjian Chen1, and Yu Guo1
1Radiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, China, 2MR Research China, GE Healthcare, Beijing, China


The main purpose was to quantitatively evaluate iron alterations in gray matter (GM) nucleus of patients with unilateral middle cerebral artery stenosis (MCAS)-related ischemic stroke using quantitative susceptibility mapping (QSM). Forty-six unilateral MCAS patients and thirty-eight healthy controls underwent QSM examination. Iron-related susceptibility of GM nucleus, including bilateral caudate nucleus, putamen (PU), globus pallidus (GP), thalamus, substantia nigra (SN), red nucleus, and dentate nucleus were assessed. Compared with healthy controls, PU, GP, and SN regions at lesion side presented significantly increased susceptibility in patients, indicating that abnormal iron metabolism may present in the brain after ischemic stroke.

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