Abstract #1747

MULTI-CONTRAST ATHEROSCLEROSIS CHARACTERIZATION (MATCH) AND MULTI-SEQUENCE MRI IN QUANTIFYING CAROTID PLAQUE COMPOSITION

Mohamed Kassem^1,2, Ellen Eline Boswijk^1,2, Jochem van der Pol^1,2, Rik PM Moonen², Jan Bucerius³, Werner H Mess⁴, Robert Jan van Oostenbrugge^1,5, Zhaoyang Fan⁶, and M Eline Kooi^1,2

¹CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands, Maastricht, Netherlands, ²Department of Radiology and Nuclear Medicine, Maastricht University medical center (MUMC+), Maastricht, Netherlands, ³Department of Nuclear Medicine, Georg-August University Göttingen, Gottingen, Germany, ⁴Department of Clinical Neurophysiology, Maastricht University medical center (MUMC+), maastricht, Netherlands, ⁵Department of Neurology, Maastricht University Medical Center+ (MUMC+), maastricht, Netherlands, ⁶Department of Radiology, University of Southern California, Los Angeles, CA, United States

Synopsis

Multi-contrast Atherosclerosis Characterization (MATCH) was developed to quantify of carotid atherosclerotic plaque composition within 5 minutes’ scan time. Twenty symptomatic patients with ≥2 mm carotid plaque underwent 3.0 Tesla conventional multi-sequence and MATCH MRI. Excellent agreement was obtained for scoring a Lipid-rich necrotic core (LRNC) intraplaque hemorrhage (IPH) on the MATCH images while fair for calcifications. No significant differences between MATCH and multi-sequence MRI were found in volume of LRNC, IPH and calcifications. We demonstrated excellent agreement between MATCH and multi-sequence MRI for the identification and quantification of LRNC and IPH within significant shorter time.

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