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Abstract #1776

A comparison of tractography and fMRI pre-surgical planning approaches with intraoperative mapping-based validation

Ahmed Radwan1,2, Louise Emsell1,2,3,4, Evy Cleeren5, Silvia Kovacs6, Anais Van Hoylandt5, Ronald Peeters6, Steven De Vleeschouwer2,5,7, Tom Theys2,5,7, Patrick Dupont2,8, and Stefan Sunaert1,2,6
1Imaging and pathology, Translational MRI, KU Leuven, Leuven, Belgium, 2Department of Neurosciences, KU Leuven, Leuven Brain Institute, Leuven, Belgium, 3Department of Neurosciences, Neuropsychiatry, KU Leuven, Leuven, Belgium, 4Geriatric Psychiatry, University Psychiatric Center (UPC) - Leuven, Leuven, Belgium, 5Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium, 6Department of Radiology, University Hospitals Leuven, Leuven, Belgium, 7Department of Neurosciences, Research Group Experimental Neurosurgery and Neuroanatomy, KU Leuven, Leuven, Belgium, 8Department of Neurosciences, Laboratory for cognitive neurology, KU Leuven, Leuven, Belgium


Accurate presurgical brain mapping enables preoperative risk assessment and intraoperative guidance to minimize postoperative deficits. Here we compare mapping accuracy of task-based fMRI (tbfMRI), BOLD and Functionnectome resting state fMRI (rsfMRI), DTI and constrained spherical deconvolution (CSD)-based tractography in 21 preoperative neurosurgical patients using intraoperative electrical stimulation (DES) as the ground truth for functional mapping. Accuracy was estimated based on minimum distance between MRI-based mapping and positive DES coordinates. We report that CSD outperforms DTI, and rsfMRI performs similarly to tbfMRI using DES. This demonstrates the potential benefits of using CSD and rsfMRI in clinical practice.

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