Abstract #1776

A comparison of tractography and fMRI pre-surgical planning approaches with intraoperative mapping-based validation

Ahmed Radwan^1,2, Louise Emsell^1,2,3,4, Evy Cleeren⁵, Silvia Kovacs⁶, Anais Van Hoylandt⁵, Ronald Peeters⁶, Steven De Vleeschouwer^2,5,7, Tom Theys^2,5,7, Patrick Dupont^2,8, and Stefan Sunaert^1,2,6

¹Imaging and pathology, Translational MRI, KU Leuven, Leuven, Belgium, ²Department of Neurosciences, KU Leuven, Leuven Brain Institute, Leuven, Belgium, ³Department of Neurosciences, Neuropsychiatry, KU Leuven, Leuven, Belgium, ⁴Geriatric Psychiatry, University Psychiatric Center (UPC) - Leuven, Leuven, Belgium, ⁵Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium, ⁶Department of Radiology, University Hospitals Leuven, Leuven, Belgium, ⁷Department of Neurosciences, Research Group Experimental Neurosurgery and Neuroanatomy, KU Leuven, Leuven, Belgium, ⁸Department of Neurosciences, Laboratory for cognitive neurology, KU Leuven, Leuven, Belgium

Synopsis

Accurate presurgical brain mapping enables preoperative risk assessment and intraoperative guidance to minimize postoperative deficits. Here we compare mapping accuracy of task-based fMRI (tbfMRI), BOLD and Functionnectome resting state fMRI (rsfMRI), DTI and constrained spherical deconvolution (CSD)-based tractography in 21 preoperative neurosurgical patients using intraoperative electrical stimulation (DES) as the ground truth for functional mapping. Accuracy was estimated based on minimum distance between MRI-based mapping and positive DES coordinates. We report that CSD outperforms DTI, and rsfMRI performs similarly to tbfMRI using DES. This demonstrates the potential benefits of using CSD and rsfMRI in clinical practice.

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