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Abstract #1778

The origins of BOLD signal fluctuations in non-gas-inhalation CVR mapping: an fMRI-EEG study

Parimal Pravin Joshi1, Yi Zhang2,3, Xirui Pravin Hou2, Cuimei Xu2, Paul Bottomley2, Hanzhang Lu2, and Peiying Liu1
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Department of Radiology, Johns Hopkins University School of medicine, Baltimore, MD, United States, 3Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China


Cerebrovascular reactivity (CVR) is typically measured with hypercapnic challenges, which require considerable subject cooperation. Recent CVR mapping approaches using resting-state BOLD data are promising, but their sensitivity is low in subjects with minimal spontaneous changes in breathing pattern. Performed in conjunction with resting-state BOLD scans, intermittent breath modulation enhances variations in breathing pattern while requiring minimal subject compliance, and is a promising tool for CVR mapping without gas inhalation. Here we conducted simultaneous fMRI-EEG experiments to investigate origins of the global BOLD signal fluctuations during intermittent breath modulation, to verify the validity of this new approach.

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