Cerebrovascular reactivity (CVR) is typically measured with hypercapnic challenges, which require considerable subject cooperation. Recent CVR mapping approaches using resting-state BOLD data are promising, but their sensitivity is low in subjects with minimal spontaneous changes in breathing pattern. Performed in conjunction with resting-state BOLD scans, intermittent breath modulation enhances variations in breathing pattern while requiring minimal subject compliance, and is a promising tool for CVR mapping without gas inhalation. Here we conducted simultaneous fMRI-EEG experiments to investigate origins of the global BOLD signal fluctuations during intermittent breath modulation, to verify the validity of this new approach.
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