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Abstract #1781

A Novel Acquisition Strategy for Volumetric Diffusion-Weighted Imaging using Variable Density TSE-CASPR

Sebastian Eduardo Fonseca1, Sheng-Qing Lin1, Limin Zhou1, Yiming Wang1, and Ananth J Madhuranthakam1,2
1Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Diffusion weighted imaging (DWI) is a highly valuable MR imaging technique in the clinic. Single-shot EPI is the reference standard sequence for DWI due to its speed, however it suffers from severe distortion artifacts that can obscure potential pathologies. In this abstract, we present a novel 3D acquisition strategy that uses a fast spin echo readout and variable density sampling for volumetric DWI. The oversampled center region serves as navigator to correct phase errors. We present preliminary results in brains of healthy volunteers compared to the standard sequences used in DWI.

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