Abstract #1780

Evaluating b-value combinations on IVIM-DKI analysis with parametric reconstruction method in pancreatic carcinoma: A digital phantom study

Archana Vadiraj Malagi¹, Devasenathipathy Kandasamy², Kedar Khare³, Fernando Calamante⁴, Raju Sharma², and Amit Mehndiratta^5,6

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi, Navi Mumbai, India, ²Department of Radiodiagnosis, All India Institute of Medical Sciences Delhi, New Delhi, India, ³Department of Physics, Indian Institute of Technology Delhi, New Delhi, India, ⁴Sydney Imaging and School of Biomedical Engineering, University of Sydney, Sydney, Australia, ⁵Indian Institute of Technology Delhi, New Delhi, India, ⁶Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India

Synopsis

Optimization of b-values in IVIM-DKI is required for parameter estimation accuracy. IVIM-DKI model with Total Variation correction approach was employed in this study, which avoids abrupt changes in parameter values and eliminates non-physiological heterogeneity in maps. In pancreatic cancer, different b-value combinations were used: 4,6,8,10, and 13b-values. In terms of accurate parameter estimations and comparable qualitative maps, 8-13 b-values exhibited a similar trend; in contrast, 4b-values indicated inaccurate and noisy maps. 8b-values can be employed in pancreatic cancer with a constrained technique for a shorter acquisition process and reduced noise in parameter maps at low SNR.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.