Evaluating b-value combinations on IVIM-DKI analysis with parametric reconstruction method in pancreatic carcinoma: A digital phantom study
Archana Vadiraj Malagi1, Devasenathipathy Kandasamy2, Kedar Khare3, Fernando Calamante4, Raju Sharma2, and Amit Mehndiratta5,6
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, Navi Mumbai, India, 2Department of Radiodiagnosis, All India Institute of Medical Sciences Delhi, New Delhi, India, 3Department of Physics, Indian Institute of Technology Delhi, New Delhi, India, 4Sydney Imaging and School of Biomedical Engineering, University of Sydney, Sydney, Australia, 5Indian Institute of Technology Delhi, New Delhi, India, 6Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India
Optimization of b-values in IVIM-DKI is required for parameter estimation accuracy. IVIM-DKI model with Total Variation correction approach was employed in this study, which avoids abrupt changes in parameter values and eliminates non-physiological heterogeneity in maps. In pancreatic cancer, different b-value combinations were used: 4,6,8,10, and 13b-values. In terms of accurate parameter estimations and comparable qualitative maps, 8-13 b-values exhibited a similar trend; in contrast, 4b-values indicated inaccurate and noisy maps. 8b-values can be employed in pancreatic cancer with a constrained technique for a shorter acquisition process and reduced noise in parameter maps at low SNR.
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